Analysts’ Varied Perspectives On CytomX’s CX-904 Cancer Study: Safety Profile But Caution in Pancreatic Cancer
Wednesday, CytomX Therapeutics Inc (NASDAQ:CTMX) released initial data from the ongoing CX-904 Phase 1a dose escalation clinical study, demonstrating a favorable safety profile and confirmed anti-cancer activity.
As of April 16, 2024, data cutoff, the Phase 1 study enrolled 35 heavily pretreated patients with advanced metastatic solid tumor types.
CX-904 demonstrated a favorable safety profile, supporting administration and monitoring enrolled patients in an outpatient setting.
Eight patients had measurable tumor reduction at data cutoff, including 2 of 6 efficacy-evaluable patients (33%) with pancreatic cancer with confirmed partial responses.
All six efficacy-evaluable patients with pancreatic cancer achieved disease control (objective response or stable disease).
One patient (6 mg target dose) achieved an 83% tumor reduction for the two patients with a confirmed partial response.
The second patient (5 mg target dose) with a confirmed response achieved a 51% …
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