Home Trade Opening Bell U.S. bio-pharmaceutical company Tesaro Inc (TSRO.O) nvestment banks stock up 21.00
U.S. bio-pharmaceutical company Tesaro Inc (TSRO.O) nvestment banks stock up 21.00

U.S. bio-pharmaceutical company Tesaro Inc (TSRO.O) nvestment banks stock up 21.00


Additional clinical trial data later this year on Tesaro’s key drug, Niraparib, which targets advanced solid tumors in ovarian and breast cancers, could help narrow the valuation gap, the people said.

The sources asked not to be identified because the deliberations are confidential.

Tesaro and Citigroup declined to comment.

Tesaro shares rose as much as 17 percent on the news and were up 11 percent at $180.50 in late morning trading in New York on Wednesday, giving the company a market capitalization of more than $9 billion. Tesaro went public in 2012 at $13.50 per share.

Tesaro has been touted for months by analysts and investors as a likely acquisition target, in light of big deals in the biotechnology sector, such as Pfizer Inc’s (PFE.N) $14 billion acquisition of cancer drugmaker Medivation Inc last September, and Johnson & Johnson’s (JNJ.N) $30 billion announced acquisition last month of rare disease drugmaker Actelion Ltd (ATLN.S).

Tesaro has a coveted position as a leader in the so-called immuno-oncology sector, which harnesses the body’s own immune system to combat cancer cells.

Its drug Niraparib kills cancer cells by inhibiting the production of proteins called PARPs, which help repair damaged DNA strands, thereby hastening the death of some types of cancer cells.

Effective PARP inhibitors are particularly sought after by drugmakers because of their potential to be used in combination with other types of cancer treatments to create new breakthroughs in treatments.


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Niraparib is closer than any other PARP inhibitor to receiving regulatory approval for ovarian cancer maintenance therapy. Analysts say its peak sales could exceed $3 billion.

Last year, the U.S. Food and Drug Administration agreed to “fast-track” its Niraparib review process, raising the likelihood it could hit the market by 2018.

That would give it a significant head start over its main rival, Clovis Oncology Inc (CLVS.O), whose similar treatment is in late-stage trials.

Last year, Tesaro entered into a partnership with pharmaceutical company Merck & Co Inc (MRK.N) to study the effects of using Niraparib in combination with Keytruda, Merck’s immuno-oncology treatment.

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